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Snap-8 10mg - Research Peptide
Anti-Aging 10mg

Snap-8

$55.00 In Stock

Synthetic octapeptide for dynamic wrinkle reduction research.

≥98%
HPLC Purity
COA
Included
USA
Based Supplier

Description

Synthetic octapeptide for dynamic wrinkle reduction research.

Snap-8 (acetyl octapeptide-3) is a synthetic eight-amino acid peptide that acts as a competitive antagonist of the SNARE complex, specifically mimicking the N-terminal end of SNAP-25 to interfere with vesicular neurotransmitter release at the neuromuscular junction. By competing with native SNAP-25 for SNARE complex assembly, Snap-8 reduces the exocytosis of acetylcholine from motor neurons, thereby decreasing the intensity of muscle contractions responsible for dynamic expression lines. In vitro studies by Lipotec (now part of Lubrizol) demonstrated that Snap-8 at 0.05 mg/mL reduced SNARE complex formation by approximately 73%, while clinical evaluation showed a mean wrinkle depth reduction of approximately 63% after 28 days of topical application at 10% concentration. This mechanism is analogous to but milder than botulinum toxin, which cleaves SNARE complex proteins irreversibly rather than competing for binding sites. Compared to its predecessor argireline (acetyl hexapeptide-3/Snap-6), Snap-8 contains two additional amino acids that research indicates improve binding affinity and stability. Unlike injectable neuromodulators, Snap-8 is designed for topical research formulations and does not cross the dermal barrier in quantities sufficient to cause systemic neuromuscular effects. The peptide is water-soluble and compatible with most cosmetic research vehicles. Store lyophilized powder at -20C; for topical research formulations, dissolve in aqueous buffer at desired concentration. Snap-8 is studied by cosmetic chemistry laboratories, dermatological research institutions, and topical drug delivery researchers developing non-invasive anti-aging formulations.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 10mg of research-grade material.

Research Applications

  • Dynamic wrinkle reduction studies
  • Anti-aging cosmetic peptide research
  • Topical formulation development
  • Alternative to botulinum-based treatments

Specifications

Size
10mg
Purity
≥98% (HPLC)
Form
Lyophilized Powder
Molecular Formula
C41H70N16O16S
Molecular Weight
1075.16 g/mol

Storage & Handling

  • Long-term storage: -20°C in a sealed, light-protected container
  • Short-term storage: 2-8°C (refrigerated) for up to 30 days
  • Reconstituted: Store at 2-8°C and use within 30 days
  • Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
  • Reconstitution: Use bacteriostatic water or sterile water for injection

Frequently Asked Questions

What is Snap-8 and how does it work?
Snap-8 (acetyl octapeptide-3) is a synthetic octapeptide that mimics the N-terminal end of the SNAP-25 protein, a component of the SNARE complex responsible for neurotransmitter release at neuromuscular junctions. By competitively inhibiting SNARE complex assembly, Snap-8 has been observed in in-vitro models to reduce the exocytosis of catecholamines, thereby decreasing the muscular contractions that form dynamic facial wrinkles.
What research has been done on Snap-8?
Studies published in the International Journal of Cosmetic Science demonstrated that Snap-8 reduced wrinkle depth by up to 63% in clinical evaluations of topical formulations. In-vitro research showed dose-dependent inhibition of catecholamine release from chromaffin cells. Comparative studies have positioned Snap-8 as an extension of Argireline (acetyl hexapeptide-3), with the additional two amino acids providing enhanced receptor binding affinity.
How does Snap-8 compare to Argireline (Acetyl Hexapeptide-3)?
Snap-8 is an extended version of Argireline, containing 8 amino acids versus Argireline's 6. Both target the SNARE complex to reduce neuromuscular signaling, but Snap-8's longer sequence has demonstrated improved binding affinity and greater efficacy in comparative in-vitro assays. Published research suggests Snap-8 achieves similar or better wrinkle-reducing effects at lower concentrations than Argireline in topical formulation research.
What is the recommended reconstitution protocol for Snap-8?
For this 10mg vial, reconstitute with 2mL of bacteriostatic water for a 5mg/mL solution. Snap-8 dissolves readily within 1-2 minutes due to its relatively low molecular weight (1075.16 g/mol). For topical research applications, the reconstituted solution can be incorporated into vehicle formulations. Store at 2-8°C and use within 30 days.
What purity testing is performed on Snap-8?
Snap-8 purity is verified by reverse-phase HPLC at a minimum threshold of 98%. Molecular identity is confirmed by ESI mass spectrometry against the expected 1075.16 g/mol molecular weight. Additional testing includes amino acid analysis, peptide content quantification, and endotoxin screening. A batch-specific Certificate of Analysis (COA) is provided with every order.

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Research Use Only. This product is not intended for human consumption, therapeutic use, or diagnostic purposes. All peptides sold by Elyte Peptides are strictly for in-vitro research and laboratory use. By purchasing, you agree to use this product in compliance with all applicable laws and regulations.