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Epithalon 10mg - Research Peptide
Anti-Aging 10mg

Epithalon

$59.00 In Stock

Synthetic tetrapeptide for telomerase activation and longevity research.

≥98%
HPLC Purity
COA
Included
USA
Based Supplier

Description

Synthetic tetrapeptide for telomerase activation and longevity research.

Epithalon (also known as Epitalon or epithalamin) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology in Russia. Its primary mechanism of action involves activation of telomerase, the enzyme responsible for adding telomeric repeats (TTAGGG) to chromosome ends, thereby counteracting the progressive telomere shortening associated with cellular aging. Published research by Khavinson and colleagues (Bulletin of Experimental Biology and Medicine, 2003) demonstrated that epithalon increased telomerase activity in human somatic cells and extended the replicative lifespan of fibroblast cultures beyond the Hayflick limit. In animal studies, chronic epithalon administration in aging rats was associated with increased lifespan and restoration of melatonin secretion rhythms from the pineal gland, which naturally declines with age (Anisimov et al., Mechanisms of Ageing and Development, 2003). The peptide also appears to modulate expression of genes involved in antioxidant defense and circadian rhythm regulation. Compared to other telomerase activators such as TA-65 (a small molecule derived from astragalus), epithalon is a direct peptide bioregulator with a well-characterized tetrapeptide sequence. Research also suggests potential effects on retinal health, with studies indicating photoreceptor preservation in aging retinal models. Store lyophilized powder at -20C protected from moisture; reconstitute with bacteriostatic water and refrigerate at 2-8C for up to 21 days. Epithalon is studied by gerontology research centers, telomere biology laboratories, and chronobiology departments investigating age-related decline in pineal gland function.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 10mg of research-grade material.

Research Applications

  • Telomerase activation and telomere protection
  • Longevity and cellular aging studies
  • Melatonin regulation and circadian rhythm
  • Skin repair and wound healing

Specifications

Size
10mg
Purity
≥98% (HPLC)
Form
Lyophilized Powder

Storage & Handling

  • Long-term storage: -20°C in a sealed, light-protected container
  • Short-term storage: 2-8°C (refrigerated) for up to 30 days
  • Reconstituted: Store at 2-8°C and use within 30 days
  • Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
  • Reconstitution: Use bacteriostatic water or sterile water for injection

Frequently Asked Questions

What is Epithalon and how does it work?
Epithalon (also spelled Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural pineal gland peptide epithalamin. It has been observed in preclinical and cell culture studies to activate telomerase, the enzyme responsible for adding protective telomere sequences to chromosome ends. By promoting telomere maintenance, Epithalon is studied for its potential role in cellular longevity and the regulation of age-related gene expression.
What research has been done on Epithalon?
Professor Vladimir Khavinson's research at the Saint Petersburg Institute of Biogerontology (published in Bulletin of Experimental Biology and Medicine) demonstrated that Epithalon activated telomerase in human somatic cells and extended the lifespan of fibroblast cultures beyond the Hayflick limit. Additional studies showed Epithalon influenced melatonin secretion patterns in aging animal models and improved retinal function in age-related retinal degeneration research.
How does Epithalon compare to other telomerase-activating compounds like TA-65?
TA-65 is a plant-derived telomerase activator (cycloastragenol from Astragalus membranaceus) that works through a different mechanism than Epithalon. Epithalon directly influences telomerase gene expression as a peptide bioregulator, while TA-65 activates telomerase indirectly through its small-molecule pathway. Epithalon's peptide structure allows for more targeted research on the relationship between peptide signaling and telomere biology.
What is the recommended reconstitution protocol for Epithalon?
For this 10mg vial, reconstitute with 1mL of bacteriostatic water for a 10mg/mL solution. Epithalon is a small tetrapeptide that dissolves almost immediately (under 1 minute). Add bacteriostatic water along the vial wall. Store reconstituted solution at 2-8°C and use within 30 days.
What purity testing is performed on Epithalon?
Epithalon purity is confirmed by HPLC analysis (minimum 98%). Given its small size as a tetrapeptide, molecular identity is verified by mass spectrometry and amino acid analysis to ensure correct sequence (Ala-Glu-Asp-Gly). Additional tests include water content, residual solvent screening, and endotoxin quantification. A Certificate of Analysis (COA) is included.

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Research Use Only. This product is not intended for human consumption, therapeutic use, or diagnostic purposes. All peptides sold by Elyte Peptides are strictly for in-vitro research and laboratory use. By purchasing, you agree to use this product in compliance with all applicable laws and regulations.