Thymalin

Description

Thymus-derived polypeptide for immune regulation research.

Thymalin is a polypeptide complex originally extracted from calf thymus glands, standardized as a mixture of short peptides including the dipeptide Glu-Trp (EW). Developed by Vladimir Khavinson and colleagues at the Saint Petersburg Institute of Bioregulation and Gerontology, Thymalin operates through thymic bioregulation, restoring T-cell populations and normalizing the ratio of T-helper to T-suppressor lymphocytes. It modulates thymulin production and supports immune homeostasis through gene expression changes in immunocompetent cells. Landmark longevity research by Khavinson and Morozov published in Neuroendocrinology Letters reported that Thymalin administration in a 6-year study of elderly subjects was associated with a 2-fold reduction in mortality rate compared to controls, alongside improvements in immune markers, endocrine function, and cardiovascular parameters. Additional studies published in Bulletin of Experimental Biology and Medicine showed restoration of melatonin production and normalization of cortisol rhythms in aged subjects receiving Thymalin. Research in animal models demonstrated increased average and maximum lifespan when Thymalin was administered to aging rodents. Compared to Thymosin Alpha-1, which is a defined single-sequence peptide with extensive Western clinical data, Thymalin represents a complex bioregulatory approach rooted in the Russian peptide bioregulator tradition. Thymosin Alpha-1 has more targeted receptor-level data, while Thymalin's effects appear more systemic and multi-pathway. Both aim to restore immune competence, but through different pharmacological approaches. Lyophilized Thymalin should be stored at -20°C. Reconstitute with bacteriostatic water and store at 2-8°C, using within 3 weeks. Thymalin is primarily researched by gerontologists, immunologists studying age-related immune decline, and bioregulation scientists investigating peptide-based geroprotective interventions.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 10mg of research-grade material.

Research Applications

• Immune function regulation
• Anti-aging and geroprotection
• Viral infection response
• Lympholeukemia studies

Specifications

Size

10mg

Purity

≥98% (HPLC)

Form

Lyophilized Powder

Molecular Formula

C33H54N12O15

Molecular Weight

858.864 g/mol

Storage & Handling

• Long-term storage: -20°C in a sealed, light-protected container
• Short-term storage: 2-8°C (refrigerated) for up to 30 days
• Reconstituted: Store at 2-8°C and use within 30 days
• Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
• Reconstitution: Use bacteriostatic water or sterile water for injection