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Selank 10mg - Research Peptide
Cognitive 10mg

Selank

$75.00 In Stock

Synthetic tuftsin analogue for anxiety and cognitive function research.

≥98%
HPLC Purity
COA
Included
USA
Based Supplier

Description

Synthetic tuftsin analogue for anxiety and cognitive function research.

Selank is a synthetic heptapeptide analogue of the naturally occurring immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg), extended with a Pro-Gly-Pro sequence for enhanced metabolic stability. Selank exerts its effects primarily through modulation of the GABAergic system, influencing GABA-A receptor subunit expression and monoamine neurotransmitter metabolism, particularly serotonin and norepinephrine. It also demonstrates immunomodulatory activity by regulating cytokine balance and enhancing phagocytic activity. Research conducted at the Institute of Molecular Genetics in Moscow revealed that Selank significantly altered the expression of 36 genes related to GABAergic neurotransmission in hippocampal tissue (Zozulya et al., 2001). Studies in Bulletin of Experimental Biology and Medicine demonstrated anxiolytic effects comparable to benzodiazepines but without sedation, motor impairment, or dependence risk. Further work by Kozlovskii and Danchev showed that Selank enhanced memory trace stability in rodent avoidance tasks, suggesting dual anxiolytic-nootropic activity. Compared to Semax, Selank produces a calming, anxiolytic profile rather than a stimulatory cognitive boost. Where Semax primarily modulates BDNF and melanocortin pathways, Selank operates through GABA modulation and immune regulation. Diazepam and other classical anxiolytics share Selank's target system but carry tolerance and withdrawal risks that research suggests Selank does not. Store lyophilized Selank at -20°C in a desiccated environment. After reconstitution with bacteriostatic water, refrigerate at 2-8°C and use within 3-4 weeks. Selank is primarily studied by neuropharmacologists, behavioral researchers investigating anxiety models, and immunologists examining peptide-based immune modulation.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 10mg of research-grade material.

Research Applications

  • Anxiety management and GABA modulation
  • Immunomodulation studies
  • Cognitive enhancement and memory
  • Pain modulation via opioid receptors

Specifications

Size
10mg
Purity
≥98% (HPLC)
Form
Lyophilized Powder
Molecular Formula
C33H57N11O9
Molecular Weight
751.87 g/mol
CAS Number
129954-34-3

Storage & Handling

  • Long-term storage: -20°C in a sealed, light-protected container
  • Short-term storage: 2-8°C (refrigerated) for up to 30 days
  • Reconstituted: Store at 2-8°C and use within 30 days
  • Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
  • Reconstitution: Use bacteriostatic water or sterile water for injection

Frequently Asked Questions

What is Selank and how does it work?
Selank is a synthetic heptapeptide based on the naturally occurring immunopeptide tuftsin (Thr-Lys-Pro-Arg) with an added Gly-Pro sequence for stability. It has been observed to modulate GABAergic neurotransmission, stabilize enkephalins (endogenous opioid peptides), and influence the expression of interleukin-6 and other immune markers. These combined anxiolytic, nootropic, and immunomodulatory properties make it a multi-target research compound.
What research has been done on Selank?
Selank was developed at the Institute of Molecular Genetics (Russian Academy of Sciences) and approved in Russia as an anxiolytic. Published research in Bulletin of Experimental Biology and Medicine demonstrated anxiolytic effects comparable to benzodiazepines but without sedation or dependence. Studies showed Selank modulates the expression of 36 genes involved in GABAergic neurotransmission. Additional research has explored its immunostimulatory effects through tuftsin pathway activation.
How does Selank compare to benzodiazepines or Semax?
Unlike benzodiazepines, Selank modulates GABA signaling without direct receptor binding, avoiding sedation, tolerance, and dependence observed with traditional anxiolytics. Compared to Semax (which upregulates BDNF for cognitive enhancement), Selank's primary mechanism involves enkephalin stabilization and immune modulation. Researchers studying anxiety models typically choose Selank, while cognitive enhancement models favor Semax.
What is the recommended reconstitution protocol for Selank?
For this 10mg vial, reconstitute with 2mL of bacteriostatic water for a 5mg/mL solution. Selank dissolves readily within 1-2 minutes (751.87 g/mol molecular weight). For intranasal delivery research, reconstitution with sterile saline may be more appropriate. Store at 2-8°C and use within 30 days.
What purity testing is performed on Selank?
Selank undergoes reverse-phase HPLC for purity verification (minimum 98%), mass spectrometry for identity confirmation (751.87 g/mol), and amino acid analysis. The tuftsin core sequence integrity is specifically verified. Additional tests include endotoxin quantification, residual solvent screening, and peptide content analysis. A batch-specific Certificate of Analysis (COA) is provided.

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Research Use Only. This product is not intended for human consumption, therapeutic use, or diagnostic purposes. All peptides sold by Elyte Peptides are strictly for in-vitro research and laboratory use. By purchasing, you agree to use this product in compliance with all applicable laws and regulations.