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NAD+ 500mg 500mg - Research Peptide
Mitochondrial 500mg

NAD+ 500mg

$149.00 In Stock

Essential coenzyme for energy production and DNA repair research.

≥98%
HPLC Purity
COA
Included
USA
Based Supplier

Description

Essential coenzyme for energy production and DNA repair research.

NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme present in every living cell, serving as a critical electron carrier in metabolic redox reactions including glycolysis, the citric acid cycle, and oxidative phosphorylation. Beyond energy metabolism, NAD+ functions as a substrate for sirtuins (SIRT1-7), poly(ADP-ribose) polymerases (PARPs) involved in DNA repair, and CD38/CD157 ectoenzymes involved in calcium signaling. NAD+ levels decline significantly with age, and this decline has been implicated as a driver of metabolic dysfunction and cellular senescence. Seminal research by Imai and Guarente (2014) in Trends in Cell Biology established the NAD+ depletion theory of aging, demonstrating that declining NAD+ levels impair sirtuin activity and mitochondrial function. Studies by Yoshino et al. (2011) in Cell Metabolism showed that NAD+ precursor supplementation restored metabolic function in aged and diet-induced obese mice. Research in Science by Li et al. demonstrated that NAD+ repletion improved muscle stem cell function and extended lifespan in aged murine models through SIRT1-dependent mechanisms. This 500mg formulation provides a direct NAD+ supply for research applications. Compared to precursors like NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside), which require enzymatic conversion, direct NAD+ bypasses biosynthetic pathway bottlenecks, though its larger molecular size presents different cellular uptake considerations. Each approach offers distinct advantages depending on the research model. Store lyophilized NAD+ at -20°C, protected from light and moisture, as it is hygroscopic. Reconstitute with bacteriostatic water and store at 2-8°C, using within 2-3 weeks, as NAD+ is susceptible to hydrolytic degradation in solution. NAD+ is studied by aging researchers, metabolic scientists, DNA repair biologists, and mitochondrial function specialists.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 500mg of research-grade material.

Research Applications

  • Aging and metabolic health studies
  • Neurodegenerative disease research
  • DNA repair and ischemic stress
  • Liver, kidney, and cardiac function

Specifications

Size
500mg
Purity
≥98% (HPLC)
Form
Lyophilized Powder
Molecular Formula
C21H27N7O14P2
Molecular Weight
663.43 g/mol

Storage & Handling

  • Long-term storage: -20°C in a sealed, light-protected container
  • Short-term storage: 2-8°C (refrigerated) for up to 30 days
  • Reconstituted: Store at 2-8°C and use within 30 days
  • Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
  • Reconstitution: Use bacteriostatic water or sterile water for injection

Frequently Asked Questions

What is NAD+ and how does it work?
NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme found in every living cell that participates in over 500 enzymatic reactions. It serves as an electron carrier in metabolic reactions (glycolysis, TCA cycle, oxidative phosphorylation) and as a substrate for enzymes including sirtuins (SIRT1-7), PARPs (poly-ADP-ribose polymerases), and CD38. These enzymes regulate DNA repair, gene expression, circadian rhythms, and cellular stress responses.
What research has been done on NAD+?
Published research in Cell (2013) by Dr. David Sinclair demonstrated that NAD+ depletion drives age-related mitochondrial dysfunction and that replenishment restored mitochondrial function in aging mice. Studies in Science showed NAD+ supplementation activated sirtuins and extended lifespan in model organisms. Clinical research has investigated NAD+ for neurodegenerative conditions (Alzheimer's, Parkinson's), ischemic brain injury, and metabolic syndrome.
How does NAD+ 500mg compare to NMN or NR supplementation?
NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are oral NAD+ precursors that must be converted to NAD+ through enzymatic pathways. Direct NAD+ provides the active coenzyme without requiring conversion steps, bypassing potential rate-limiting enzyme bottlenecks. The 500mg size is suitable for standard research protocols, while our 1000mg option is available for higher-dose studies.
What is the recommended reconstitution protocol for NAD+ 500mg?
For this 500mg vial, reconstitute with 5mL of bacteriostatic water for a 100mg/mL solution. NAD+ (663.43 g/mol) dissolves readily within 2-3 minutes. The solution should be clear to slightly yellow — significant discoloration indicates degradation. NAD+ is sensitive to light and heat. Store reconstituted solution at 2-8°C, protected from light, and use within 14 days.
What purity testing is performed on NAD+ 500mg?
NAD+ purity is verified by HPLC (minimum 98%) with specific monitoring for NADH (the reduced form) and degradation products including nicotinamide. UV-Vis spectrophotometry confirms the characteristic absorption at 260nm (and absence of significant 340nm absorption, which would indicate NADH contamination). Mass spectrometry, endotoxin testing, and water content analysis are performed. A COA is included.

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Research Use Only. This product is not intended for human consumption, therapeutic use, or diagnostic purposes. All peptides sold by Elyte Peptides are strictly for in-vitro research and laboratory use. By purchasing, you agree to use this product in compliance with all applicable laws and regulations.